Author Information

Manuscript Formatting
Manuscript formats must be in accordance with the ICMJE-Recommendations for the Conduct, Reporting, Editing and Publication of Scholarly Work in Medical Journals (updated in December 2015). Manuscripts that do not follow the instructions of Worldwide Medicine will be returned to the authors for correction without further review. Therefore, the authors must carefully review the format of the journal to avoid loss of time and work. 
The Editors of Worldwide Medicine hold the right to make all the necessary changes to the language and style of the original manuscript in order to adhere to the uniform standards of the journal. 

General Format 
The manuscript files should be written in English in understandable style and checked for correct spelling and grammar. Authors whose first language is not English are strongly advised to have their manuscript edited by a language professional or native English speaker before the submission. 
The manuscript should be typed in a Microsoft Word file, single-column format, 1.5 spaced with 2 cm margins on each side, and 8-point type in Helvetica font. 
All abbreviations in the text must be defined the first time they are used (both in the abstract and the main text), and the abbreviations should be displayed in parentheses after the definition. Abbreviations should be limited to those defined in the AMA Manual of Style, current edition. Authors should avoid abbreviations in the title and abstract. 
The manuscript files should not contain any information about the authors and affiliation. This is important because all manuscripts are sent for blind peer review. Author contributions, conflict of interest and funding sources must be stated at the end of the manuscript before references. 

Article Types 
The main article types of the journal are listed below: 

Original Article: Original articles are manuscripts including substantial novel research such as randomized controlled trials, observational (cohort, case-control or cross-sectional) studies, descriptive studies, diagnostic accuracy studies, nonrandomized behavioral and public health intervention trials or experimental animal trials. Abstracts should not exceed 300 words and should be structured with these subheadings: Background, Methods, Results and Conclusions. The main text should be structured with these subheadings: Introduction, Methods, Results, Discussion, Acknowledgements, References. The manuscript should not exceed 5000 words, excluding abstract, references, tables and figure legends. There should be a maximum of 50 references. 

Brief Report: Brief reports are short and peer-reviewed articles containing small case series, negative trials, the preliminary results and others that are not to be published as an original article. The manuscript should be less than 2000 words with a maximum 20 references and have no more than 3 display items (tables or figures). Abstracts should not exceed 250 words and should be structured with these subheadings: Background, Methods, Results and Conclusions. The main text should be structured with these subheadings: Introduction, Methods, Results, Discussion, Acknowledgements, References. 

Review Article: Review articles are determined as detailed analyses of specific subjects in medicine. All review articles will also undergo peer review process. Review articles must not exceed 5000 words for the main text (excluding abstract, references, tables and figure legends) and 300 words for the abstract. The abstract does not need to be structured. A review article can have no more than 100 references. 

Case Report: Interesting rare cases including a substantial novel finding can be reported. Abstracts of case reports should include information about the case and should be limited to a maximum of 250 words. The abstract does not need to be structured. The paper of case reports should be structured with these subheadings: Introduction, Case Report, Discussion and References. Case reports must not exceed 1500 words (excluding abstract, references, tables and figure legends). Case reports can have no more than 15 references and 3 figures or tables. 

Clinical Image: Worldwide Medicine may publish original, interesting and high quality clinical images that have brief explanations (maximum 500 words, excluding references and figure legends). It can have no more than 5 references and 1 figure or table. Any information that might identify the patient should be removed from the image. An abstract is not required with this type of papers. The main text of clinical images should be structured with these subheadings: Case and References. 

Letter to the Editor: Letters in reference to a journal article must not exceed 500 words (excluding references). Letters not related to a journal article must also not exceed 500 words (excluding references). An abstract is not required with this type of papers. A letter can have no more than 5 references and 1 figure or table. Authors might be asked for a reply to the letter. Replies must be submitted through submission system as well. 

Editorial Comment: Editorial comment is a brief remark on an article published in the journal by the reviewer of the article or by a relevant authority. Most comments are invited by the Editor-in-Chief, but spontaneous comments are welcome. It must not exceed 750 words (excluding references). An abstract is not required with this type of papers. It can have no more than 10 references and 1 figure or table. 

Others: Editorials, book reviews and reports on publication and research ethics are requested by the Editorial Board. 
 

These are not definite limits and may vary slightly depending on the condition of the article. 

Clinical Trials 
Worldwide Medicine encourages the registration of all clinical trials via ClinicalTrials.gov or one of the registries of the WHO’s International Clinical Trials Registry Platform. The name of the registry and the registration number together with the information of funding source should be provided at the end of the abstract. 

Manuscript Preparation and Submission 
The submission process for a manuscript is completely online through the following website:https://www.ejmanager.com/my/im/. Please note that each corresponding author is asked to suggest two potential reviewers during the manuscript submission process. The corresponding author may also suggest opposing reviewers (optional). 

The submission should be divided into separate files in the following order: 
1. Cover Letter 
2. Title Page 
3. Main Document (abstract, keywords, main text, references, tables and figure legends. The main document should not contain any information about the authors and affiliation) 
4. Figures 
5. Authorship Contributions Form 
6. Copyright Transfer Form 
7. The ICMJE Conflict of Interest Form 

Cover Letter 
The cover letter should be a separate file and include the article title, article type and the full name of the corresponding author. The corresponding author should briefly describe the study and why the study is valuable for the scientific literature and give any other information regarding the manuscript that the Editors may find useful. The cover letter should also contain a statement declaring the absence or presence of a conflict of interest. Additionally, there should be a statement that the manuscript has not already been published, accepted or under simultaneous review for publication elsewhere. For manuscripts that have been presented orally or as a poster, this must be stated on the title page with the date and the place of the presentation. 

Title Page 
The title page should be a separate file and include the complete manuscript title, the authors’ full names, affiliations (institution, department, city, country) and e-mail addresses, the corresponding author’s e-mail address and full mailing address (institution, department, street, street number, zip code, city, country). Please be informed that the e-mail address of corresponding author will be published in the final version of the article if it is accepted. For studies that have been presented orally or as a poster, the title page must include the information about where and when the study has previously been presented. 

Main Document 
The main document should include the abstract, keywords, main text, references, tables and figure legends, respectively. Please be informed that the cover letter and title page are not included in the main file. Any information that may indicate an individual or institution should be excluded from the main document to ensure a blinded review process. 

Abstract 
Original articles, review articles, brief reports and case reports should include an abstract. Abstracts for original articles and brief reports should be structured with these subheadings: Background, Methods, Results and Conclusions. Abstracts for review articles and case reports do not need to be structured. Clinical Images, Editorials, Letters to the Editor and Commentaries should not contain an abstract. 

Keywords 
Please provide 3-10 keywords from the MeSH database, when possible, available at: http://www.nlm.nih.gov/mesh/meshhome.html 

Introduction 
In the introduction section, the authors should highlight new information in the manuscript, the hypothesis, and the aim of their work. The introduction section should not contain any results or conclusions. 

Methods 
The methods section should include the design and setting of the study, the characteristics of participants or description of materials, a clear description of all processes, interventions and comparisons and the type of statistical analysis used. 
Laboratory values should be expressed using the International System of Units (SI). Generic drug names should generally be used. When proprietary brands are used in research, include the brand names in parentheses. The instruments (give the manufacturer’s name, town, and country in parentheses), and procedures should be described in sufficient detail to allow other researchers to reproduce the results. For well-established methods, only references should be provided. 
When reporting trials on human subjects, authors should indicate whether the procedures were in accordance with the ethical standards set by the responsible human experimentation committee (institutional and national) and Helsinki Declaration. All subjects should sign an informed consent form and this information should be expressed in the manuscript. Signed informed consent forms should be archived by the authors. The authors have to provide a written statement that they have received and archived all patient informed consent forms. 

Results 
The results section should include the main or most important findings. The data presented in the tables or figures should not be repeated in the text. Graphs may be used as an alternative to tables with many entries. However, the same data should not be presented in both graphs and tables. Exact p-values should be provided for all tested differences (e.g., write p=0.024 instead of p<0.05) rounded to three decimal places. 

Discussion 
The authors should emphasize the new and important conclusion based on the study results in the context of the best available evidence. The authors should not repeat the data presented in the introduction or results section. The limitation of the study should be stated. 

Acknowledgments 
All contributors who do not meet the criteria for authorship should be listed in the acknowledgments section. Financial and material support should also be acknowledged. 

Author Contributions 
The individual contributions of authors to the manuscript should be specified in this section. In addition, it should be noted that all co-authors have seen and approved the final version of the paper and have agreed to its submission for publication. The corresponding author should send the Authorship Contributions Form during submission process. 

The ICMJE recommends that authorship is based on the following four criteria: 
1. Substantial contributions to the conception or design of the work; or the acquisition, analysis, or interpretation of data for the work 
2. Drafting the work or revising it critically for important intellectual content 
3. Final approval of the version to be published 
4. Agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. 
A contributor should meet all four criteria to be identified as an author. If a contributor does not meet all four criteria he/she should be acknowledged in the acknowledgements. 

Conflict of Interest 
In this section, the authors should indicate whether there is a conflict of interest, or not. All financial and non-financial competing interests must be declared in this section. If you do not have any competing interests, please state "The authors declare that they have no conflict of interest." in this section. 

Funding 
All sources of funding for the research should be declared. The role of the funding body in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript should be declared. If you do not have any funding sources, please state “The authors declare no funding for this research.” 

References 
Reference listings of Worldwide Medicine must be in accordance with ICMJE standards and numbered consecutively at the end of the manuscript in the order in which they are mentioned in the text. While citing publications, preference should be given to the latest and most up to date publications. If an ahead of print publication is being cited the DOI number should be provided. Authors are responsible for the accuracy of references. Journal titles should be abbreviated in accordance with the journal abbreviations in Index Medicus/Medline/PubMed. When there are 6 or less authors, all authors should be listed. If there are 7 or more authors the first 6 authors should be listed followed by “et al”. In the main text of the manuscript, references should be cited using Arabic numbers in brackets. The reference styles for different types of publications are presented in the following examples: 

Journal article: Rose ME, Huerbin MB, Melick J, Marion DW, Palmer AM, Schiding JK, et al. Regulation of interstitial excitatory amino acid concentrations after cortical contusion injury. Brain Res 2002;935:40-6. 

Book: Murray PR, Rosenthal KS, Kobayashi GS, Pfaller MA. Medical microbiology. 4th ed. St. Louis: Mosby; 2002. 

Book chapter: Meltzer PS, Kallioniemi A, Trent JM. Chromosome alterations in human solid tumors. In: Vogelstein B, Kinzler KW, editors. The genetic basis of human cancer. New York: McGraw-Hill; 2002:93-113. 

Abstract: Lofwall MR, Strain EC, Brooner RK, Kindbom KA, Bigelow GE. Characteristics of older methadone maintenance (MM) patients (abstract). Drug Alcohol Depend 2002;66:105. 

Article in electronic format: Morse SS. Factors in the emergence of infectious diseases. Emerg Infect Dis (serial online) 1995 Jan-Mar (cited 1996 June 5): 1(1): (24 screens). Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626828/pdf/8903148.pdf. 

Tables 
Tables should be presented within the main document after the reference list. All tables should be referred to within the main text and they should be numbered consecutively in the order they are referred to within the main text. A descriptive title should be provided for all tables and the titles should be placed above the tables. Abbreviations used in the tables should be defined below the tables. Tables should be created using the “insert table” command of the word processing software and they should be arranged clearly to provide an easy reading. 

Figures and Figure Legends 
Figures, graphics and photographs should be submitted as separate files (tiff, jpeg or png format) through the submission system. They should not be embedded in the Microsoft Word document. When there are figure subunits, the subunits should not be merged to form a single image. Each subunit should be submitted separately through the submission system. Images should not be labelled (a, b, c, etc.) to indicate figure subunits. Thick and thin arrows, arrowheads, stars, asterisks and similar marks can be used on the images to support figure legends. The minimum resolution of each submitted figure should be 300 DPI and all submitted figures should be clear in resolution. 
Figure legends should be listed at the end of the main document. When there are figure subunits, the figure legends should be structured in the following format. 

Copyright 
The authors must sign the Copyright Transfer Agreement Form and submit it through the submission system during submission. 

ORCID 
ORCID IDs of all authors should be stated during the submission of manuscript. ORCID IDs will be increase transparence of journal and authors, it will also prevent the confusions caused by name similarities and affiliations. ORCID also increases the visibility of author and their works by keeping profiles up-to-date. All authors can create free accounts on https://orcid.org and get the personal 16-digits number. 

Appeals and Complaints 
Appeal and complaint cases are handled within the scope of COPE guidelines by the Editorial Board of Worldwide Medicine. Appeals should be based on the scientific content of the manuscript. The final decision on the appeal and complaint is made by the Editor-in-Chief. The authors should get in contact with the Editor-in-Chief regarding their appeals and complaints via e-mail at theinternationalmedicine@gmail.com 

Proofs and DOI Number 
The manuscripts accepted for publication are provided with a DOI number immediately after acceptance. Accepted manuscripts are copy-edited for grammar, punctuation, and format. Once the publication process of a manuscript is completed it is published online on the journal’s webpage in Articles in Press before it is included in its scheduled issue. A PDF proof of the accepted manuscript is sent to the corresponding author and their publication approval is requested within 2 days of their receipt of the proof. 

Submission and Publication Fees 
Worldwide Medicine is an open access fully refereed international medical journal without any submission and publication fees. All costs are sponsored by the Editorial Board of the journal.